Research Summary: Effect of Caffeine and Caffeine Cessation on Cerebrovascular Reactivity in Migraine Patients

Summarized by Nina Riggins, MD, Ph.D., FAHS Many migraine patients consume caffeine on a regular basis. The question is, what is the relationship between caffeine intake and migraine conditions? This study’s objective was to discuss the effect of caffeine and caffeine cessation on cerebrovascular reactivity in patients with migraine. Continue reading to learn more about the study’s findings. Study Overview Migraine is associated with several vascular disorders. Mechanisms of associations between migraine and stroke are still under research. The objective of the study was to investigate the effect of chronic caffeine use and subsequent caffeine cessation on vasodilatory function in...
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Research Summary: Second-line Interventions for Migraine in the Emergency Department

Summarized by Anna Pace, MD Headache®: The Journal of Head and Face Pain published “Second-line interventions for migraine in the emergency department: A narrative review.” Millions of patients visit emergency departments (ED) each year for the treatment of migraine. However, for up to one-third of treated patients, first-line agents like metoclopramide, prochlorperazine and sumatriptan fail to provide sufficient relief. This study’s objective was to discuss the evidence supporting the use of second-line agents for migraine patients in the ED who didn’t improve adequately after treatment with first-line medications. Study Methods The authors identified all medications reviewed in the “AHS Management...
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Migraine in Pregnancy

Discusses how to prepare for, and manage, migraine during pregnancy, as well as headache "red flags" to be alert to while pregnant....
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Research Summary: A narrative review of the importance of pharmacokinetics and drug–drug interactions of preventive therapies in migraine management

Summarized by Richard Kim, MD  Headache®: The Journal of Head and Face Pain published “A narrative review of the importance of pharmacokinetics and drug–drug interactions of preventive therapies in migraine management.” Migraine is a disabling neurological disorder requiring acute therapy for attacks, with many patients being a candidate for preventive treatment. Many patients with migraine also have comorbid conditions that need to be addressed, such as anxiety, depression, cardiovascular disease, asthma, sleep disorders, and other chronic pain conditions, which can make treatment challenging due to potential drug-drug interactions (DDIs). Many DDIs result from the coadministration of multiple drugs that undergo...
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